Delta Rana IV colony was a Federation colony on the planet Delta Rana IV in the Delta Rana system.

The entire colony was destroyed by the Husnock in 2366. All but one of the 11,000 colonists were killed and the planet surface was ravaged. The colonist were unable to flee as the colony had no interstellar spacecraft at its disposal. The sole survivor, actually a Douwd in Human form traveling under the name Kevin Uxbridge who moved to the colony in 2361, used his enormous powers to destroy the entire Husnock species in retribution. Later, Uxbridge remained in self-imposed isolation on Delta Rana IV. (TNG: "The Survivors")