The Daystrom Prize was an award given to people who have made significant scientific and technical achievements.

At some point prior to 2376, Doctor Lewis Zimmerman won the Daystrom Prize for holography. (VOY: "Life Line")

In 2378, the USS Voyager crew predicted that Reginald Barclay would win the Daystrom Prize for making the first trans-galactic commlink. (VOY: "Author, Author")