• Philip Anglim as Bareil Antos
• David B. Levinson as Broik
• Majel Barrett as Lwaxana Troi
• Jeffrey Combs as Brunt
• Casey Biggs as Damar
• Marc Alaimo as S.G. Dukat
• Kenneth Marshall as Michael Eddington
• Salome Jens as Female Changeling
• James Darren as Vic Fontaine
• Andrew Robinson as Elim Garak
• Todd Slayton as Thot Gor
• Robert O'Reilly as Gowron
• Andrea Martin as Ishka
• Cecily Adams as Ishka
• Charlie-Olisa Kaine as Ensign Kelly
• John Colicos as Kor
• Chase Masterson as Leeta
• Tiny Ron as Maihar'du
• J.G. Hertzler as Martok
• Mark Allen Shepherd as Morn
• Cathy DeBuono as M'Pella
• Aron Eisenberg as Nog
• Rosalind Chao as Keiko O'Brien
• Kirayoshi O'Brien
• Hana Hatae as Molly O'Brien
• Camille Saviola as Opaka
• Leslie Bevis as Rionoj
• Max Grodénchik as Rom
• Barry Jenner as William Ross
• Duncan Regehr as Shakaar Edon
• Brock Peters as Joseph Sisko
• Deborah Lacey as Sarah Sisko
• William Sadler as Luther Sloan
• Paul Dooley as Enabran Tain
• Cyia Batten as Tora Ziyal
• Tracy Middendorf as Tora Ziyal
• Melanie Smith as Tora Ziyal
• Jeffrey Combs as Weyoun
• Louise Fletcher as Winn Adami
• Penny Johnson as Kasidy Yates
• Wallace Shawn as Zek
• (Judy Durand as the Cardassian Computer Voice)
• (Majel Barrett as the Federation Computer Voice)