A Cardassian frigate was a type of frigate operated by the Cardassians during the 24th century.

While still operating as Maquis in the Alpha Quadrant, Chakotay, B'Elanna Torres and Seska successfully disabled the computer core on the Cardassian frigate orbiting Bajor. This was accomplished when Seska modified an antiproton beam to penetrate the frigate's shields and hull from an extremely close range.

In 2372, Chakotay suggested using this tactic to disable a Kazon-Nistrum starship, commanded by First Maje Culluh. He later unsuccessfully attempted to implement it himself, after taking a shuttlecraft and locating the Kazon vessel, but was outmaneuvered by Seska during his attempt. (VOY: "Maneuvers")