In 2331, the first Federation outpost was established on Boradis III. Between that time and 2365 the Federation had colonized several planets. Four colonies were present in the Boradis system itself and nine outposts were present in the sector Boradis was located in.
Thirty-four years later, the USS Enterprise-D intercepted a Class-8 probe occupied by Special Federation Emissary K'Ehleyr, with orders from Starfleet for a new mission. The new mission required the Enterprise to intercept a Klingon sleeper ship from the late 23rd century. (TNG: "The Emissary")