The planet was relatively close to Planet Q and Cygnia Minor. At warp 2, Benecia was located approximately 48 hours away from Camus II. The location of Benecia in the Milky Way Galaxy was depicted on a Federation star chart in 2293. (TOS: "The Conscience of the King", "Turnabout Intruder"; Star Trek VI: The Undiscovered Country, production art)
In 2266, the Karidian Company intended to play two Shakespeare performances on Benecia. After the attempted murder of Captain James T. Kirk, Lenore Karidian, the daughter of Governor Kodos, was institutionalized on Benecia. She had been murdering the survivors of the Tarsus IV massacre who could identify her father. In Doctor Leonard McCoy's opinion, she would receive the best of care available on Benecia. (TOS: "The Conscience of the King")
In 2269, Commander Spock judged the medical facilities of the colony to be most primitive, not suited to diagnose and treat radiation sickness. Janice Lester, who had transferred her consciousness to the body of Kirk, ordered the ship to set course to Benecia, to buy herself time to kill Captain Kirk whose consciousness was trapped in her original body. (TOS: "Turnabout Intruder")
"The Explored Galaxy"
"The Explored Galaxy" was a map of charted space in the Alpha Quadrant. Benecia was located between the Tholian Assembly and Romulus. Both locations were identified in DS9: "The Search, Part II", "Call to Arms" as being located in this quadrant. The chart, first seen chronologically in Star Trek VI: The Undiscovered Country, was also seen in several Star Trek: The Next Generation and Star Trek: Deep Space Nine episodes set in the 24th century, from the year 2364 to 2370. These were TNG: "Conspiracy", "The Measure Of A Man", "The Emissary", "The Mind's Eye", "The Game", and DS9: "In the Hands of the Prophets", "Cardassians".
- Benecia (Benecia Colony): In 2378, this planet was a Federation member. ("United Federation of Planets I")
- Benecia system: This planetary system was located in or near Federation space, in the Alpha Quadrant. This was a binary star system. Benecia A was a K-class star with a magnitude of +5, which was the same brightness as Sol. Benecia B was a K-class star. ("United Federation of Planets III")