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The Antwerp Conference was a high level meeting between Romulan and Federation diplomats, held in the city of Antwerp in the European Alliance on Earth in 2372. The conference was attended by many dignitaries, including one Tholian observer.

The Antwerp Conference was the site of the first confirmed Dominion attack on Earth. An explosive planted by a changeling killed 27 people, the worst attack of its kind on Earth in more than a century. After the bombing, Federation President Jaresh-Inyo declared a planetwide day of mourning.

The bombing was partly the cause of an attempted coup against the Federation President by Admiral Leyton (DS9:"Homefront", "Paradise Lost").

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