Ensign Angie Kirby was a Starfleet operations division officer who served aboard the USS Defiant, under Captain Benjamin Sisko during the 2370s.

A week after she came aboard, in late 2373, the Defiant entered the atmosphere of a planet (later named "Gaia") and discovered a settlement of the crew's descendants from an alternate timeline. In the alternate timeline, the crew of the Defiant were sent back in time 200 years, and marooned on the planet.

In this timeline, Angie Kirby and Doctor Bashir married and procreated leaving the planet "crawling with Bashirs" by the time the Defiant made its visit. However, when the Defiant failed to go back in time and fulfill its "destiny", the colony presumably ceased to exist. (DS9: "Children of Time")

In 2374, she participated in an attack on a Dominion sensor array in the Argolis Cluster. Afterward, she found it difficult to believe that Julian Bashir had helmed the Defiant after Lieutenant Haj had been injured. (DS9: "Behind the Lines")