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The Andromeda Galaxy was the closest galaxy to the Milky Way Galaxy. (TOS: "By Any Other Name")

The Messier Catalog number for this galaxy was M31.Both the Andromeda and the Milky Way were located within the Local Group of galaxies. (Star Trek: Star Charts, page 10}.

A picture of the Andromeda Galaxy was on display in the briefing room of the USS Enterprise when the crew was reviewing star charts to search for the origin of an unknown buoy. (TOS: "The Corbomite Maneuver")

An image of the galaxy was on display on one of the large bridge monitors aboard the USS Enterprise. (TOS: "Charlie X", "The Naked Time", "The Galileo Seven", "Dagger of the Mind")

An ancient humanoid race from the Andromeda Galaxy became extinct following the destruction of their homeworld when their sun went supernova. Remnants of the species survived for a time on scattered outposts but eventually died out, leaving their android populations on their own. One of these android-populated outposts was the planet Mudd in the Milky Way Galaxy. (TOS: "I, Mudd")

Centuries ago, Kelvans became aware of dangerously rising radiation levels in Andromeda, a development expected to make that galaxy uninhabitable for their species within 10,000,000 years (or "10,000 milenia"). The Kelvan Empire dispatched expeditions of multi-generational starships to explore the neighboring galaxies for territories suitable for conquest and occupation. (TOS: "By Any Other Name")

Hypothetically, a Constitution-class starship running at maximum warp would take thousands of years to complete the journey to Andromeda. (TOS: "By Any Other Name")

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