Alexander the Great (356-323 BCE) was a mighty conqueror, who was able to conquer most of the world, as it was then known to the people in Europe and the Middle East. He is generally considered one of (if not the) greatest generals who ever lived.
A 23rd century analogy made regarding the creation of the Augments, a race known their superior ability and ambition, was compared to creating a group of Alexanders or Napoléons. (TOS: "Space Seed")
Spock put him in one line with Ramses, Julius Caesar, Napoléon, Adolf Hitler and Lee Kuan to show that Earth history is full of men seeking absolute power. (TOS: "Patterns of Force")
It was later revealed, in 2269, that the immortal Flint was, in fact, the former Alexander. (TOS: "Requiem for Methuselah")
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