This point in time represents a hideout for members of the Q Continuum. The USS Voyager was briefly transported here by Quinn in order to escape Q, but he too had once used this hideout and was thus able to find the ship. (VOY: "Death Wish")
The age of the universe was given in VOY: "Good Shepherd" as 16 billion years, which was the estimated age during the filming of the episode. Current real-world scientific evidence indicates the age of the universe to be 13.798 ± 0.037 billion years.
Some of Earth's dinosaurs survive the asteroid impact and continue to develop and name themselves the Voth. Sometime thereafter they leave Earth and travel to the Delta quadrant where they create one of the first interstellar empires in the quadrant. (VOY: "Distant Origin")
Captain Jean Luc Picard stated in his log that the ancient Bajorans had flourished "when Humans were not yet standing erect". Homo Erectus existed on Earth from about 1.8 million years to about 200,000 years ago. Homo Sapiens began to emerge at about 200,000 years ago.
An ancient city was built on Bajor with walls and a tablet that were dated to be over thirty millennia old. This city was inhabited until twenty-five thousand years ago after which, sediment buried the ruins and the ancient city of B'hala was built on top of it. (DS9: "The Reckoning")
A species of intelligent spacefaring organisms which form symbiotic relationships with humanoid lifeforms that live within their bodies become nearly extinct. Gomtuu is the last known survivor. (TNG: "Tin Man")
The first of the Orbs is discovered by the Bajorans in the sky above their planet. Over the next ten millennia, a total of nine of these extraordinary objects are discovered, inspiring revelations that shape Bajoran religion. (DS9: "Emissary")
A power struggle occurs within the highest ranks of a race called the Saltah'na, which ultimately destroys them. Before their extinction, the Saltah'na create a collection of energy spheres which preserve a record of the events leading to the species' destruction via a telepathic matrix, which can be transferred into the minds of some humanoid species, causing them to reenact the power struggle. (DS9: "Dramatis Personae")