The 2240s were an important decade for Federation space exploration, with the commissioning of new starship class vessels Constitution and Enterprise, which would come to be known as Constitution-class starships. Captained by Robert T. April, with wife Sarah April as CMO, Enterprise would experience many exploration firsts in her long career, which began in 2245. These new ships benefited from advances in warp drive which came along with the breaking of the time barrier, and also new computer advancements such as duotronics, invented by Richard Daystrom in this decade.
- The PXK pergium-powered nuclear reactor goes out of common use. One notable exception is the Janus VI colony. (TOS: "The Devil in the Dark")
- The decade would also include one of the worst crimes in Federation history when 4,000 colonists at Tarsus IV would be put to death at the orders of Governor Kodos. (TOS: "The Conscience of the King")
- During this decade, a young James T. Kirk went for a joyride in his stepfather's Corvette, bailing out just as the car fell into a deep quarry. (Star Trek)