- An attempt at viral genetic engineering, the life prolongation complex, annihilates all life except prepubescent children on a distant planet that is a physical copy of Earth. The complex halts aging in these children, who survive for at least 300 more years, until the USS Enterprise discovers them in 2266. (TOS: "Miri")
- The Earth Cold War rises to dangerous levels of hostilities, viewed by several major powers as a possible catalyst for World War III. To keep a political edge, many nations fund extensive espionage programs. Centuries later, the Deep Space 9 holosuite holoprograms "Julian Bashir, Secret Agent" and "Bashir 62" will be set during this period.
- The city of Las Vegas will see its "golden age" in the 1960s. Centuries later, the holo-program "Vic's Las Vegas Lounge" will be set during this decade.