The 15th century is defined by the calendar of Earth as occurring from the year 1401 through the year 1500.
- After the Turei render their homeworld uninhabitable by plasma weapon bombardments, a battalion of approximately six hundred Vaadwaur warriors takes refuge below the planet's surface in a state of cryostasis. Intending to remain in stasis for only five years, they are eventually woken up when USS Voyager visits their planet 892 years later. (VOY: "Dragon's Teeth")
- On Februari 19 Nicolaus Copernicus is born in Toruń, Poland. (VOY: "Future's End")
- A rating of "B" on the industrial scale corresponds to a technology level equal to that of Earth's in this year. (TOS: "Spock's Brain")
|14th century||Timeline||16th century|